Amazing Spider-Man Vol 1 (1963) #44 Vgfn

Cover by John Romita Sr. Second appearance of the Lizard in "Where Crawls the Lizard," script by Stan Lee, art by John Romita Sr.; Dr. Connors reacts from The Rhino antidote he was previously working on and turns into The Lizard; Realizing this, he runs away but is spotted by his son Billy; The Lizard plots his human conquest and plans to defeat Spider-Man.